Nuclear Import and Export of Viruses and Virus Genomes
نویسندگان
چکیده
منابع مشابه
Nuclear import and export of plant virus proteins and genomes.
SUMMARY Nuclear import and export are crucial processes for any eukaryotic cell, as they govern substrate exchange between the nucleus and the cytoplasm. Proteins involved in the nuclear transport network are generally conserved among eukaryotes, from yeast and fungi to animals and plants. Various pathogens, including some plant viruses, need to enter the host nucleus to gain access to its repl...
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It remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core protein (HBc) and particles. To address this fundamental issue, we have identified four distinct HBc localization signals in the arginine rich domain (ARD) of HBc, using immunofluorescence confocal microscopy and fractionation/Western blot analysis. ARD consists of four tight clustering arginine-rich...
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The Rev protein of HIV-1 actively shuttles between nucleus and cytoplasm and mediates the export of unspliced retroviral RNAs. The localization of shuttling proteins such as Rev is controlled by the relative rates of nuclear import and export. To study nuclear export in isolation, we generated cell lines expressing a green fluorescent protein-labeled chimeric protein consisting of HIV-1 Rev and...
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The new coronavirus (COVID-19) is caused by the acute respiratory syndrome 2. The disease was first diagnosed in December 2019 in Hubei Province, Wuhan City, China. On March 11, the World Health Organization declared the virus an epidemic. Until Mid-February, 2021, about 112 million people worldwide have been infected with the virus, of which about 2.500.000 people have lost their lives, accord...
متن کاملMultiple vesiculoviral matrix proteins inhibit both nuclear export and import.
The matrix (M) protein of vesicular stomatitis virus inhibits both nuclear import and export. Here, we demonstrate that this inhibitory property is conserved between the M proteins from two other vesiculoviruses, chandipura virus and spring viremia carp virus. All three M proteins completely block nuclear transport of spliced mRNA, small nuclear RNAs, and small nuclear ribonucleoproteins and sl...
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ژورنال
عنوان ژورنال: Virology
سال: 1998
ISSN: 0042-6822
DOI: 10.1006/viro.1998.9165